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Clinical Therapeutics, 29 (11), 2269-2288

The fact that the best-fitting model was quadratic rather than strictly linear is itself informative: it suggests that pushing the dose to 6.0 mg did not buy additional histologic benefit and may have shifted the tolerability balance, exactly the kind of nuance a dose-finding trial exists to surface

Physical therapy helps but progress can be painfully slow

Benefits: May help support comfort during episodes of nausea Promotes overall treatment tolerance Note: Administered only at the discretion of a licensed healthcare provider

This is particularly relevant for patients receiving regular hydroxocobalamin injections for pernicious anaemia or malabsorption conditions